Autologous olfactory ensheathing cell transplantation in human paraplegia : a 3-year clinical trial. Commentary
Identifieur interne : 008E61 ( Main/Exploration ); précédent : 008E60; suivant : 008E62Autologous olfactory ensheathing cell transplantation in human paraplegia : a 3-year clinical trial. Commentary
Auteurs : Volker Dietz [Suisse] ; A. Mackay-Sim [Australie] ; F. Feron [Australie, France] ; J. Cochrane [Australie] ; L. Bassingthwaighte [Australie] ; C. Bayliss [Australie] ; W. Davies [Australie] ; P. Fronek [Australie] ; C. Gray [Australie] ; G. Kerr [Australie] ; P. Licina [Australie] ; A. Nowitzke [Australie] ; C. Perry [Australie] ; P. A. S. Silburn [Australie] ; S. Urquhart [Australie] ; T. Geraghty [Australie]Source :
- Brain [ 0006-8950 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Olfactory ensheathing cells show promise in preclinical animal models as a cell transplantation therapy for repair of the injured spinal cord. This is a report of a clinical trial of autologous transplantation of olfactory ensheathing cells into the spinal cord in six patients with complete, thoracic paraplegia. We previously reported on the methods of surgery and transplantation and the safety aspects of the trial I year after transplantation. Here we address the overall design of the trial and the safety of the procedure, assessed during a period of 3 years following the transplantation surgery. All patients were assessed at entry into the trial and regularly during the period of the trial. Clinical assessments included medical, psychosocial, radiological and neurological, as well as specialized tests of neurological and functional deficits (standard American Spinal Injury Association and Functional Independence Measure assessments). Quantitative test included neurophysiological tests of sensory and motor function below the level of injury. The trial was a Phase 1/lla design whose main aim was to test the feasibility and safety of transplantation of autologous olfactory ensheathing cells into the injured spinal cord in human paraplegia. The design included a control group who did not receive surgery, otherwise closely matched to the transplant recipient group. This group acted as a control for the assessors, who were blind to the treatment status of the patients. The control group also provided the opportunity for preliminary assessment of the efficacy of the transplantation.There were no adverse findings 3 years after autologous transplantation of olfactory ensheathing cells into spinal cords injured at least 2 years prior to transplantation.The magnetic resonance images (MRls) at 3 years showed no change from preoperative MRls or intervening MRls at I and 2 years, with no evidence of any tumour of introduced cells and no development of post-traumatic syringomyelia or other adverse radiological findings.There were no significant functional changes in any patients and no neuropathic pain. In one transplant recipient, there was an improvement over 3 segments in light touch and pin prick sensitivity bilaterally, anteriorly and posteriorly. We conclude that transplantation of autologous olfactory ensheathing cells into the injured spinal cord is feasible and is safe up to 3 years of post-implantation, however, this conclusion should be considered preliminary because of the small number of trial patients.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 003348
- to stream PascalFrancis, to step Curation: 002D04
- to stream PascalFrancis, to step Checkpoint: 003390
- to stream Main, to step Merge: 009804
- to stream Main, to step Curation: 008E61
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Autologous olfactory ensheathing cell transplantation in human paraplegia : a 3-year clinical trial. Commentary</title><author><name sortKey="Dietz, Volker" sort="Dietz, Volker" uniqKey="Dietz V" first="Volker" last="Dietz">Volker Dietz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Spinal Cord Injury Centre, Balgrist University Hospital, Forchstr. 340</s1><s2>8008 Zürich</s2><s3>CHE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Mackay Sim, A" sort="Mackay Sim, A" uniqKey="Mackay Sim A" first="A." last="Mackay-Sim">A. Mackay-Sim</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Centre for Adult Stem cell Research, Eskitis Institute for Cell and MolecularTherapies, Griffith University</s1><s2>Brisbane, Qld 4111</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Qld 4111</wicri:noRegion></affiliation></author><author><name sortKey="Feron, F" sort="Feron, F" uniqKey="Feron F" first="F." last="Feron">F. Feron</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Centre for Adult Stem cell Research, Eskitis Institute for Cell and MolecularTherapies, Griffith University</s1><s2>Brisbane, Qld 4111</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Qld 4111</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Neurobiologie des Interactions Cellulaire et Neurophysiopathologie, CNRS UMR 6184, IFR Jean Roche, Faculté de Médecine Nord, Bd Pierre Dramard</s1><s2>13916 Marseille</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>13916 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Cochrane, J" sort="Cochrane, J" uniqKey="Cochrane J" first="J." last="Cochrane">J. Cochrane</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Centre for Adult Stem cell Research, Eskitis Institute for Cell and MolecularTherapies, Griffith University</s1><s2>Brisbane, Qld 4111</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Qld 4111</wicri:noRegion></affiliation></author><author><name sortKey="Bassingthwaighte, L" sort="Bassingthwaighte, L" uniqKey="Bassingthwaighte L" first="L." last="Bassingthwaighte">L. Bassingthwaighte</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Occupational Therapy Department, Ipswich Hospital</s1><s2>Ipswich, Qld 4305</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Ipswich, Qld 4305</wicri:noRegion></affiliation></author><author><name sortKey="Bayliss, C" sort="Bayliss, C" uniqKey="Bayliss C" first="C." last="Bayliss">C. Bayliss</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Spinal Outreach Team, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Davies, W" sort="Davies, W" uniqKey="Davies W" first="W." last="Davies">W. Davies</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Spinal Injuries Unit, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Fronek, P" sort="Fronek, P" uniqKey="Fronek P" first="P." last="Fronek">P. Fronek</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Spinal Injuries Unit, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Gray, C" sort="Gray, C" uniqKey="Gray C" first="C." last="Gray">C. Gray</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Mental Health, Gold Coast Hospital</s1><s2>Southport, Qld 4215</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Southport, Qld 4215</wicri:noRegion></affiliation></author><author><name sortKey="Kerr, G" sort="Kerr, G" uniqKey="Kerr G" first="G." last="Kerr">G. Kerr</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>School of Human Movement Studies & Institute of Health and Biomedical Innovation, Queensland University of Technology</s1><s2>Kelvin Grove, Qld 4059</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Kelvin Grove, Qld 4059</wicri:noRegion></affiliation></author><author><name sortKey="Licina, P" sort="Licina, P" uniqKey="Licina P" first="P." last="Licina">P. Licina</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Northside Spinal Research Group, Holy Spirit Northside Hospital</s1><s2>Chermside, Qld 4302</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Chermside, Qld 4302</wicri:noRegion></affiliation></author><author><name sortKey="Nowitzke, A" sort="Nowitzke, A" uniqKey="Nowitzke A" first="A." last="Nowitzke">A. Nowitzke</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurosurgery, Head and Neck Surgery, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Perry, C" sort="Perry, C" uniqKey="Perry C" first="C." last="Perry">C. Perry</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Silburn, P A S" sort="Silburn, P A S" uniqKey="Silburn P" first="P. A. S." last="Silburn">P. A. S. Silburn</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Centre for Adult Stem cell Research, Eskitis Institute for Cell and MolecularTherapies, Griffith University</s1><s2>Brisbane, Qld 4111</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Qld 4111</wicri:noRegion></affiliation></author><author><name sortKey="Urquhart, S" sort="Urquhart, S" uniqKey="Urquhart S" first="S." last="Urquhart">S. Urquhart</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Spinal Injuries Unit, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Geraghty, T" sort="Geraghty, T" uniqKey="Geraghty T" first="T." last="Geraghty">T. Geraghty</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Spinal Injuries Unit, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0417141</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0417141 INIST</idno><idno type="RBID">Pascal:08-0417141</idno><idno type="wicri:Area/PascalFrancis/Corpus">003348</idno><idno type="wicri:Area/PascalFrancis/Curation">002D04</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003390</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003390</idno><idno type="wicri:doubleKey">0006-8950:2008:Dietz V:autologous:olfactory:ensheathing</idno><idno type="wicri:Area/Main/Merge">009804</idno><idno type="wicri:Area/Main/Curation">008E61</idno><idno type="wicri:Area/Main/Exploration">008E61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Autologous olfactory ensheathing cell transplantation in human paraplegia : a 3-year clinical trial. Commentary</title><author><name sortKey="Dietz, Volker" sort="Dietz, Volker" uniqKey="Dietz V" first="Volker" last="Dietz">Volker Dietz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Spinal Cord Injury Centre, Balgrist University Hospital, Forchstr. 340</s1><s2>8008 Zürich</s2><s3>CHE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Mackay Sim, A" sort="Mackay Sim, A" uniqKey="Mackay Sim A" first="A." last="Mackay-Sim">A. Mackay-Sim</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Centre for Adult Stem cell Research, Eskitis Institute for Cell and MolecularTherapies, Griffith University</s1><s2>Brisbane, Qld 4111</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Qld 4111</wicri:noRegion></affiliation></author><author><name sortKey="Feron, F" sort="Feron, F" uniqKey="Feron F" first="F." last="Feron">F. Feron</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Centre for Adult Stem cell Research, Eskitis Institute for Cell and MolecularTherapies, Griffith University</s1><s2>Brisbane, Qld 4111</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Qld 4111</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Neurobiologie des Interactions Cellulaire et Neurophysiopathologie, CNRS UMR 6184, IFR Jean Roche, Faculté de Médecine Nord, Bd Pierre Dramard</s1><s2>13916 Marseille</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>13916 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Cochrane, J" sort="Cochrane, J" uniqKey="Cochrane J" first="J." last="Cochrane">J. Cochrane</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Centre for Adult Stem cell Research, Eskitis Institute for Cell and MolecularTherapies, Griffith University</s1><s2>Brisbane, Qld 4111</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Qld 4111</wicri:noRegion></affiliation></author><author><name sortKey="Bassingthwaighte, L" sort="Bassingthwaighte, L" uniqKey="Bassingthwaighte L" first="L." last="Bassingthwaighte">L. Bassingthwaighte</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Occupational Therapy Department, Ipswich Hospital</s1><s2>Ipswich, Qld 4305</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Ipswich, Qld 4305</wicri:noRegion></affiliation></author><author><name sortKey="Bayliss, C" sort="Bayliss, C" uniqKey="Bayliss C" first="C." last="Bayliss">C. Bayliss</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Spinal Outreach Team, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Davies, W" sort="Davies, W" uniqKey="Davies W" first="W." last="Davies">W. Davies</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Spinal Injuries Unit, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Fronek, P" sort="Fronek, P" uniqKey="Fronek P" first="P." last="Fronek">P. Fronek</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Spinal Injuries Unit, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Gray, C" sort="Gray, C" uniqKey="Gray C" first="C." last="Gray">C. Gray</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Mental Health, Gold Coast Hospital</s1><s2>Southport, Qld 4215</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Southport, Qld 4215</wicri:noRegion></affiliation></author><author><name sortKey="Kerr, G" sort="Kerr, G" uniqKey="Kerr G" first="G." last="Kerr">G. Kerr</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>School of Human Movement Studies & Institute of Health and Biomedical Innovation, Queensland University of Technology</s1><s2>Kelvin Grove, Qld 4059</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Kelvin Grove, Qld 4059</wicri:noRegion></affiliation></author><author><name sortKey="Licina, P" sort="Licina, P" uniqKey="Licina P" first="P." last="Licina">P. Licina</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Northside Spinal Research Group, Holy Spirit Northside Hospital</s1><s2>Chermside, Qld 4302</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Chermside, Qld 4302</wicri:noRegion></affiliation></author><author><name sortKey="Nowitzke, A" sort="Nowitzke, A" uniqKey="Nowitzke A" first="A." last="Nowitzke">A. Nowitzke</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurosurgery, Head and Neck Surgery, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Perry, C" sort="Perry, C" uniqKey="Perry C" first="C." last="Perry">C. Perry</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Silburn, P A S" sort="Silburn, P A S" uniqKey="Silburn P" first="P. A. S." last="Silburn">P. A. S. Silburn</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Centre for Adult Stem cell Research, Eskitis Institute for Cell and MolecularTherapies, Griffith University</s1><s2>Brisbane, Qld 4111</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Qld 4111</wicri:noRegion></affiliation></author><author><name sortKey="Urquhart, S" sort="Urquhart, S" uniqKey="Urquhart S" first="S." last="Urquhart">S. Urquhart</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Spinal Injuries Unit, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author><author><name sortKey="Geraghty, T" sort="Geraghty, T" uniqKey="Geraghty T" first="T." last="Geraghty">T. Geraghty</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Spinal Injuries Unit, Queensland Spinal Cord Injuries Service, Princess Alexandra Hospital</s1><s2>Woolloongabba, Qld 4102</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Woolloongabba, Qld 4102</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autologous system</term><term>Clinical trial</term><term>Human</term><term>Nervous system diseases</term><term>Paraplegia</term><term>Spinal cord trauma</term><term>Transplantation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Paraplégie</term><term>Traumatisme de la moelle épinière</term><term>Pathologie du système nerveux</term><term>Système autologue</term><term>Transplantation</term><term>Homme</term><term>Essai clinique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfactory ensheathing cells show promise in preclinical animal models as a cell transplantation therapy for repair of the injured spinal cord. This is a report of a clinical trial of autologous transplantation of olfactory ensheathing cells into the spinal cord in six patients with complete, thoracic paraplegia. We previously reported on the methods of surgery and transplantation and the safety aspects of the trial I year after transplantation. Here we address the overall design of the trial and the safety of the procedure, assessed during a period of 3 years following the transplantation surgery. All patients were assessed at entry into the trial and regularly during the period of the trial. Clinical assessments included medical, psychosocial, radiological and neurological, as well as specialized tests of neurological and functional deficits (standard American Spinal Injury Association and Functional Independence Measure assessments). Quantitative test included neurophysiological tests of sensory and motor function below the level of injury. The trial was a Phase 1/lla design whose main aim was to test the feasibility and safety of transplantation of autologous olfactory ensheathing cells into the injured spinal cord in human paraplegia. The design included a control group who did not receive surgery, otherwise closely matched to the transplant recipient group. This group acted as a control for the assessors, who were blind to the treatment status of the patients. The control group also provided the opportunity for preliminary assessment of the efficacy of the transplantation.There were no adverse findings 3 years after autologous transplantation of olfactory ensheathing cells into spinal cords injured at least 2 years prior to transplantation.The magnetic resonance images (MRls) at 3 years showed no change from preoperative MRls or intervening MRls at I and 2 years, with no evidence of any tumour of introduced cells and no development of post-traumatic syringomyelia or other adverse radiological findings.There were no significant functional changes in any patients and no neuropathic pain. In one transplant recipient, there was an improvement over 3 segments in light touch and pin prick sensitivity bilaterally, anteriorly and posteriorly. We conclude that transplantation of autologous olfactory ensheathing cells into the injured spinal cord is feasible and is safe up to 3 years of post-implantation, however, this conclusion should be considered preliminary because of the small number of trial patients.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Suisse</li></country><region><li>Canton de Zurich</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li><li>Zurich</li></settlement></list><tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Dietz, Volker" sort="Dietz, Volker" uniqKey="Dietz V" first="Volker" last="Dietz">Volker Dietz</name></region></country><country name="Australie"><noRegion><name sortKey="Mackay Sim, A" sort="Mackay Sim, A" uniqKey="Mackay Sim A" first="A." last="Mackay-Sim">A. Mackay-Sim</name></noRegion><name sortKey="Bassingthwaighte, L" sort="Bassingthwaighte, L" uniqKey="Bassingthwaighte L" first="L." last="Bassingthwaighte">L. Bassingthwaighte</name><name sortKey="Bayliss, C" sort="Bayliss, C" uniqKey="Bayliss C" first="C." last="Bayliss">C. Bayliss</name><name sortKey="Cochrane, J" sort="Cochrane, J" uniqKey="Cochrane J" first="J." last="Cochrane">J. Cochrane</name><name sortKey="Davies, W" sort="Davies, W" uniqKey="Davies W" first="W." last="Davies">W. Davies</name><name sortKey="Feron, F" sort="Feron, F" uniqKey="Feron F" first="F." last="Feron">F. Feron</name><name sortKey="Fronek, P" sort="Fronek, P" uniqKey="Fronek P" first="P." last="Fronek">P. Fronek</name><name sortKey="Geraghty, T" sort="Geraghty, T" uniqKey="Geraghty T" first="T." last="Geraghty">T. Geraghty</name><name sortKey="Gray, C" sort="Gray, C" uniqKey="Gray C" first="C." last="Gray">C. Gray</name><name sortKey="Kerr, G" sort="Kerr, G" uniqKey="Kerr G" first="G." last="Kerr">G. Kerr</name><name sortKey="Licina, P" sort="Licina, P" uniqKey="Licina P" first="P." last="Licina">P. Licina</name><name sortKey="Nowitzke, A" sort="Nowitzke, A" uniqKey="Nowitzke A" first="A." last="Nowitzke">A. Nowitzke</name><name sortKey="Perry, C" sort="Perry, C" uniqKey="Perry C" first="C." last="Perry">C. Perry</name><name sortKey="Silburn, P A S" sort="Silburn, P A S" uniqKey="Silburn P" first="P. A. S." last="Silburn">P. A. S. Silburn</name><name sortKey="Urquhart, S" sort="Urquhart, S" uniqKey="Urquhart S" first="S." last="Urquhart">S. Urquhart</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Feron, F" sort="Feron, F" uniqKey="Feron F" first="F." last="Feron">F. Feron</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008E61 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008E61 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:08-0417141
|texte= Autologous olfactory ensheathing cell transplantation in human paraplegia : a 3-year clinical trial. Commentary
}}
| This area was generated with Dilib version V0.6.33. |  |